abstract：Purpose:Mapping of epithelial thickness (ET) is useful for detection of keratoconus, a disease characterized by corneal thinning and bulging in which epithelial thinning occurs over the apex. In prior clinical studies, optical coherence tomography (OCT) measurements of ET were systematically thinner than those obtained...

journal_title：Translational vision science & technology

authors： Rohrbach D,Silverman RH,Chun D,Lloyd HO,Urs R,Mamou J

更新日期：2018-04-11 00:00:00

abstract：Purpose:Semiautomated software applications derive quantitative retinal vascular parameters from fundus camera images. However, the extent of agreement between measurements from different applications is unclear. We evaluate the agreement between retinal measures from two software applications, the Singapore "I" Vessel...

journal_title：Translational vision science & technology

authors： McGrory S,Taylor AM,Pellegrini E,Ballerini L,Kirin M,Doubal FN,Wardlaw JM,Doney ASF,Dhillon B,Starr JM,Trucco E,Deary IJ,MacGillivray TJ

更新日期：2018-03-23 00:00:00

abstract：Purpose:We tested the hypotheses that retinal venule diameter (Dv) is associated with baseline intracranial pressure (ICP) level and that Dv is reduced shortly after ICP lowering. Methods:Dv and arteriole diameter (Da) were extracted from scanning laser ophthalmoscopic images in 40 eyes of 20 adult human subjects (10 ...

journal_title：Translational vision science & technology

authors： Moss HE,Vangipuram G,Shirazi Z,Shahidi M

更新日期：2018-03-19 00:00:00

abstract：Purpose:Glaucoma drainage device (GDD) implantation can lead to corneal decompensation. We evaluated changes over time in oxygen tension and in the metabolic environment of the aqueous humor after GDD implantation in the rabbit eye. Methods:Ahmed Glaucoma Valves were implanted in the left eyes of eight male New Zealan...

journal_title：Translational vision science & technology

authors： Williamson BK,Hawkey NM,Blake DA,Frenkel JW,McDaniel KP,Davis JK,Satija C,Beazer A,Dhungana S,Carlson J,McRitchie S,Ayyala RS

更新日期：2018-02-02 00:00:00

abstract：Purpose:We quantified the interrelationship between retinal blood vessel (BV) anatomical variation, spherical equivalent (SE) of refractive error, and functional diagnostic parameters in glaucoma to identify optimal parameters for the improvement of optical coherence tomography (OCT) retinal nerve fiber layer thickness...

journal_title：Translational vision science & technology

authors： Wang M,Jin Q,Wang H,Li D,Baniasadi N,Elze T

更新日期：2018-01-18 00:00:00

abstract：PURPOSE:To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS:This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-os...

journal_title：Translational vision science & technology

authors： Deinema LA,Vingrys AJ,Chinnery HR,Downie LE

更新日期：2017-05-22 00:00:00

abstract：PURPOSE:Human long (L) and middle (M) wavelength cone opsin genes are highly variable due to intermixing. Two L/M cone opsin interchange mutants, designated LIAVA and LVAVA, are associated with clinical diagnoses, including red-green color vision deficiency, blue cone monochromacy, cone degeneration, myopia, and Bornho...

journal_title：Translational vision science & technology

authors： Greenwald SH,Kuchenbecker JA,Rowlan JS,Neitz J,Neitz M

更新日期：2017-05-10 00:00:00

abstract：PURPOSE:With increasing volumes of electronic health record data, algorithm-driven extraction may aid manual extraction. Visual acuity often is extracted manually in vision research. The total visual acuity extraction algorithm (TOVA) is presented and validated for automated extraction of visual acuity from free text, ...

journal_title：Translational vision science & technology

authors： Baughman DM,Su GL,Tsui I,Lee CS,Lee AY

更新日期：2017-03-06 00:00:00

abstract：PURPOSE:Identifying potential biomarkers for disease progression in retinitis pigmentosa (RP) is highly relevant now that gene therapy and other treatments are in clinical trial. Here we report a novel technique for analysis of short-wavelength autofluorescence (AF) imaging to quantify defined regions of AF in RP patie...

journal_title：Translational vision science & technology

authors： Jolly JK,Wagner SK,Moules J,Gekeler F,Webster AR,Downes SM,MacLaren RE

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate and compare the release of moxifloxacin from a variety of daily disposable (DD) contact lenses (CLs) under various conditions using a novel in vitro eye model. METHODS:Four commercially available DD conventional hydrogel (CH) CLs (nelfilcon A, omafilcon A, etafilcon A, and...

journal_title：Translational vision science & technology

authors： Phan CM,Bajgrowicz-Cieslak M,Subbaraman LN,Jones L

更新日期：2016-11-08 00:00:00

abstract：PURPOSE:The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of Stargardt Disease (STGD) participating in the SAR422459 (NCT01367444) gene therapy clinical trial. METHODS:Twenty-two participants, aged 24 to 66, diagno...

journal_title：Translational vision science & technology

authors： Parker MA,Choi D,Erker LR,Pennesi ME,Yang P,Chegarnov EN,Steinkamp PN,Schlechter CL,Dhaenens CM,Mohand-Said S,Audo I,Sahel J,Weleber RG,Wilson DJ

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Crowdsourcing is based on outsourcing computationally intensive tasks to numerous individuals in the online community who have no formal training. Our aim was to develop a novel online tool designed to facilitate large-scale annotation of digital retinal images, and to assess the accuracy of crowdsource grading...

journal_title：Translational vision science & technology

authors： Mitry D,Zutis K,Dhillon B,Peto T,Hayat S,Khaw KT,Morgan JE,Moncur W,Trucco E,Foster PJ,1 for the UK Biobank Eye and Vision Consortium.

更新日期：2016-09-21 00:00:00

abstract：PURPOSE:We evaluate solutions for an applanating surface modification to the Goldmann tonometer prism, which substantially negates the errors due to patient variability in biomechanics. METHODS:A modified Goldmann or correcting applanation tonometry surface (CATS) prism is presented which was optimized to minimize the...

journal_title：Translational vision science & technology

authors： McCafferty S,Lim G,Duncan W,Enikov E,Schwiegerling J

更新日期：2016-09-09 00:00:00

abstract：PURPOSE:To validate the performance of a new perimetric algorithm (Gradient-Oriented Automated Natural Neighbor Approach; GOANNA) in humans using a novel combination of computer simulation and human testing, which we call Artificial Scotoma Generation (ASG). METHODS:Fifteen healthy observers were recruited. Baseline c...

journal_title：Translational vision science & technology

authors： Chong LX,Turpin A,McKendrick AM

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To demonstrate that silent substitution stimuli can be used to generate electroretinograms (ERGs) that effectively isolate rod photoreceptor function in humans without the need for dark adaptation, and that this approach constitutes a viable alternative to current clinical standard testing protocols. METHODS:R...

journal_title：Translational vision science & technology

authors： Maguire J,Parry NR,Kremers J,Kommanapalli D,Murray IJ,McKeefry DJ

更新日期：2016-08-31 00:00:00

abstract：PURPOSE:Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. METHODS:In the present study, OCT-A based on a Heidelberg Engin...

journal_title：Translational vision science & technology

authors： Giannakaki-Zimmermann H,Kokona D,Wolf S,Ebneter A,Zinkernagel MS

更新日期：2016-08-18 00:00:00

abstract：PURPOSE:Endophthalmitis is a rare complication of intravitreal injection (IVI). It is recommended that povidone-iodine be the last agent applied before IVI. Patients have reported povidone-iodine application to be the most bothersome part of IVIs. Topical anesthetics have been demonstrated to have antibacterial effects...

journal_title：Translational vision science & technology

authors： Reynolds MM,Greenwood-Quaintance KE,Patel R,Pulido JS

更新日期：2016-07-05 00:00:00

abstract：PURPOSE:We developed a surgical method for localized and atraumatic removal of the retinal pigment epithelium (RPE) with a novel instrument. METHODS:Bleb retinal detachments (bRD) were raised with balanced salt solution (BSS) following vitrectomy in 27 rabbits. The RPE was scraped with 3 loop variants (polypropylene [...

journal_title：Translational vision science & technology

authors： Thieltges F,Liu Z,Brinken R,Braun N,Wongsawad W,Somboonthanakij S,Herwig M,Holz FG,Stanzel BV

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:We developed and evaluated a training procedure for marking the endpoints of the ellipsoid zone (EZ), also known as the inner segment/outer segment (IS/OS) border, on frequency domain optical coherence tomography (fdOCT) scans from patients with retinitis pigmentosa (RP). METHODS:A manual for marking EZ endpoi...

journal_title：Translational vision science & technology

authors： Ramachandran R,X Cai C,Lee D,C Epstein B,Locke KG,G Birch D,C Hood D

更新日期：2016-05-17 00:00:00

abstract：PURPOSE:To validate Gaussian mixture-model with expectation maximization (GEM) and variational Bayesian independent component analysis mixture-models (VIM) for detecting glaucomatous progression along visual field (VF) defect patterns (GEM-progression of patterns (POP) and VIM-POP). To compare GEM-POP and VIM-POP with ...

journal_title：Translational vision science & technology

authors： Yousefi S,Balasubramanian M,Goldbaum MH,Medeiros FA,Zangwill LM,Weinreb RN,Liebmann JM,Girkin CA,Bowd C

更新日期：2016-05-03 00:00:00

abstract：PURPOSE:We performed video-oculography to evaluate vergence eye movement abnormalities in students diagnosed clinically with vergence disorders. We tested the efficiency of a novel rehabilitation method and evaluated its benefits with video-oculography cross-correlated with clinical tests and symptomatology. METHODS:A...

journal_title：Translational vision science & technology

authors： Kapoula Z,Morize A,Daniel F,Jonqua F,Orssaud C,Brémond-Gignac D

更新日期：2016-03-11 00:00:00

abstract：PURPOSE:We evaluated the efficacy of column scatter plots to describe genotype-phenotype correlations in a Japanese cohort with retinitis pigmentosa (RP). METHODS:Clinical records of 121 patients with RP with identified causative mutations were reviewed. Visual acuity, central and peripheral visual fields, electroreti...

journal_title：Translational vision science & technology

authors： Ogino K,Oishi A,Oishi M,Gotoh N,Morooka S,Sugahara M,Hasegawa T,Miyata M,Yoshimura N

更新日期：2016-03-04 00:00:00

abstract：PURPOSE:To evaluate the impact of high-speed cut rates (up to 7500 cuts per minute [cpm]) on vitreous flow through various gauge probes. METHODS:An open-sky vitrectomy technique was performed on porcine eyes using the CONSTELLATION Vision System with three different gauges of dual-pneumatic probes (27+-, 25+-, and 23-...

journal_title：Translational vision science & technology

authors： Abulon DJ,Buboltz DC

更新日期：2016-02-22 00:00:00

abstract：PURPOSE:Developing a novel image enhancement method so that nonframe-averaged optical coherence tomography (OCT) images become comparable to active eye-tracking frame-averaged OCT images. METHODS:Twenty-one eyes of 21 healthy volunteers were scanned with noneye-tracking nonframe-averaged OCT device and active eye-trac...

journal_title：Translational vision science & technology

authors： Chen CL,Ishikawa H,Wollstein G,Bilonick RA,Kagemann L,Schuman JS

更新日期：2016-01-11 00:00:00

abstract：PURPOSE:No prismatic solution for peripheral field loss (PFL) has gained widespread acceptance. Field extended by prisms has a corresponding optical scotoma at the prism apices. True expansion can be achieved when each eye is given a different view (through visual confusion). We analyze the effects of apical scotomas a...

journal_title：Translational vision science & technology

authors： Apfelbaum H,Peli E

更新日期：2015-12-31 00:00:00

abstract：PURPOSE:We determined the effect of Fourier-domain optical coherence tomography (OCT) signal strength index (SSI) and cropping on retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) scan repeatability and measurement thickness. METHODS:Eyes were enrolled in the longitudinal Advanced Imaging for Gl...

journal_title：Translational vision science & technology

authors： Zhang X,Iverson SM,Tan O,Huang D

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To develop an automated method for quantifying vitreous signal intensity on optical coherence tomography (OCT), with particular application for use in the assessment of vitreous inflammation. METHODS:This retrospective, observational case-control series comprised 30 patients (30 eyes), with vitreous haze secon...

journal_title：Translational vision science & technology

authors： Keane PA,Balaskas K,Sim DA,Aman K,Denniston AK,Aslam T,And For The Equator Study Group

更新日期：2015-09-16 00:00:00

abstract：PURPOSE:A novel glaucoma drainage device (GDD) with local drug delivery (LDD) system was created and characterized for safety and effectiveness after implantation into the suprachoroidal space (SCS) of rabbit eyes. METHODS:Thin films of two different polymers, Poly(3-hydroxybutyrate) (P(3HB)) and Poly(4-hydroxybutyrat...

journal_title：Translational vision science & technology

authors： Hovakimyan M,Siewert S,Schmidt W,Sternberg K,Reske T,Stachs O,Guthoff R,Wree A,Witt M,Schmitz KP,Allemann R

更新日期：2015-06-30 00:00:00

abstract：PURPOSE:To determine the efficacy and safety of repeated intravitreal and subconjunctival administrations of sirolimus in patients with noninfectious uveitis at 1 year in the Sirolimus as a Therapeutic Approach UVEitis (SAVE) Study. METHODS:Open-label, prospective, and randomized interventional clinical trial in which...

journal_title：Translational vision science & technology

authors： Ibrahim MA,Sepah YJ,Watters A,Bittencourt M,Vigil EM,Do DV,Nguyen QD

更新日期：2015-03-10 00:00:00

abstract：PURPOSE:We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). METHODS:Seven patients with age-related macular degeneration underwent an RPE-choroid graft tra...

journal_title：Translational vision science & technology

authors： van Zeeburg EJ,Braaf B,Cereda MG,van Meurs JC,de Boer JF

更新日期：2015-01-13 00:00:00

abstract：PURPOSE:The photopic negative response (PhNR) may be useful as a tool to monitor longitudinal change in retinal ganglion cell (RGC) function. The goal was to assess PhNR test-retest reliability, and to estimate the amount of change between tests that is likely to be statistically significant for an individual test subj...

journal_title：Translational vision science & technology

authors： Tang J,Edwards T,Crowston JG,Sarossy M

更新日期：2014-11-03 00:00:00

abstract：PURPOSE:To evaluate the safety, tolerability, and intraocular pressure (IOP)-lowering effect of Latrunculin-B (Lat-B), a marine macrolide that disrupts the actin cytoskeleton, in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG). METHODS:In this Phase I, multicenter, double-masked, ra...

journal_title：Translational vision science & technology

authors： Rasmussen CA,Kaufman PL,Ritch R,Haque R,Brazzell RK,Vittitow JL

更新日期：2014-09-03 00:00:00

abstract：PURPOSE:To evaluate the effect of age on optic nerve axon counts, spectral-domain optical coherence tomography (SDOCT) scan quality, and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements in healthy monkey eyes. METHODS:In total, 83 healthy rhesus monkeys were included in this study (age range: 1.2...

journal_title：Translational vision science & technology

authors： Fortune B,Reynaud J,Cull G,Burgoyne CF,Wang L

更新日期：2014-05-22 00:00:00

abstract：PURPOSE:To determine the active ingredient in tea tree oil (TTO) responsible for its reported killing effect on Demodex mites, the most common ectoparasite found in the human skin extending to the eye. METHODS:Using a reported in vitro killing assay to measure the survival time of adult Demodex folliculorum up to 150 ...

journal_title：Translational vision science & technology

authors： Tighe S,Gao YY,Tseng SC

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:To explore the performance of patient-specific prior information, for example, from structural imaging, in improving perimetric procedures. METHODS:Computer simulation was used to determine the error distribution and presentation count for Structure-Zippy Estimation by Sequential Testing (ZEST), a Bayesian pro...

journal_title：Translational vision science & technology

authors： Denniss J,McKendrick AM,Turpin A

更新日期：2013-05-01 00:00:00

abstract：:Canaloplasty, a recently developed non-penetrating glaucoma surgical approach, may restore physiological outflow routes in primary open-angle glaucoma with less risk of severe postoperative complications than trabeculectomy. Since the inner wall of Schlemm's canal (SC) is directly in contact with the trabecular meshwo...

journal_title：Translational vision science & technology

authors： Tian B,Kaufman PL

更新日期：2013-01-31 00:00:00

abstract：PURPOSE:To examine the protective effects of antioxidants in cultured trabecular meshwork (TM) cells exposed to oxidative stress. METHODS:Primary porcine TM cells were pretreated with 50 μM resveratrol, 0.2 mM urate, 1 mM ascorbate, 1 mM reduced glutathione (rGSH), or 1 mM ρ-coumarate followed by exposure to hydrogen ...

journal_title：Translational vision science & technology

authors： Ammar DA,Hamweyah KM,Kahook MY

更新日期：2012-05-31 00:00:00